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The results of clinical trials support the many benefits of psilocybin therapy that traditional practitioners have known for millennia.  Neurologically and psychologically, psilocybin dampens the default mode network and makes it easier to break out of harmful thought patterns clearing the way for new healthier pathways, patterns, and perspectives to be developed.  Psilocybin's substantial promise in treating issues like addiction, depression, and end of life anxiety are being demonstrated more and more by western science.  A study conducted at Johns Hopkins also found that a vast majority of religious leaders participating in the study reported that their experience was one of the most spiritually significant of their lives. 

But don't take my word for it, here are links to some published examples:

 

Psilocybin Treatment for Major Depression Effective for Up to a Year for Most Patients, Study Shows (hopkinsmedicine.org)


Single-dose psilocybin-assisted therapy in major depressive disorder: a placebo-controlled, double-blind, randomised clinical trial - eClinicalMedicine (thelancet.com)

Psilocybin as a Promising Treatment for Alcohol Use Disorder | Psychology Today

Hallucinogenic Drug Psilocybin Eases Existential Anxiety in People With Life-Threatening Cancer - 12/02/2016 (hopkinsmedicine.org)

Psychedelics: Religious leaders who took psilocybin say they 'felt God' | New Scientist

Therapeutic effect of psilocybin in addiction: A systematic review - PMC (nih.gov)

And a review of the clinical evidence done by the Oregon Health Authority:

Oregon Psilocybin Advisory Board Rapid Evidence Review.pdf

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